Cardiac regeneration based on mechanisms of cardiomyocyte proliferation and differentiation
نویسندگان
چکیده
منابع مشابه
Cardiac regeneration based on mechanisms of cardiomyocyte proliferation and differentiation.
Cardiomyocyte proliferation and progenitor differentiation are endogenous mechanisms of myocardial development. Cardiomyocytes continue to proliferate in mammals for part of post-natal development. In adult mammals under homeostatic conditions, cardiomyocytes proliferate at an extremely low rate. Because the mechanisms of cardiomyocyte generation provide potential targets for stimulating myocar...
متن کاملFeatures of cardiomyocyte proliferation and its potential for cardiac regeneration
The human heart does not regenerate. Instead, following injury, human hearts scar. The loss of contractile tissue contributes significantly to morbidity and mortality. In contrast to humans, zebrafish and newts faithfully regenerate their hearts. Interestingly, regeneration is in both cases based on cardiomyocyte proliferation. In addition, mammalian cardiomyocytes proliferate during foetal dev...
متن کاملCALL FOR PAPERS Cardiac Regeneration and Repair: Mechanisms and Therapy Cardiomyocyte proliferation in cardiac development and regeneration: a guide to methodologies and interpretations
Leone M, Magadum A, Engel FB. Cardiomyocyte proliferation in cardiac development and regeneration: a guide to methodologies and interpretations. Am J Physiol Heart Circ Physiol 309: H1237–H1250, 2015. First published September 4, 2015; doi:10.1152/ajpheart.00559.2015.—The newt and the zebrafish have the ability to regenerate many of their tissues and organs including the heart. Thus, a major go...
متن کاملCardiomyocyte proliferation in cardiac development and regeneration: a guide to methodologies and interpretations.
The newt and the zebrafish have the ability to regenerate many of their tissues and organs including the heart. Thus, a major goal in experimental medicine is to elucidate the molecular mechanisms underlying the regenerative capacity of these species. A wide variety of experiments have demonstrated that naturally occurring heart regeneration relies on cardiomyocyte proliferation. Thus, major ef...
متن کاملA microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice.
In contrast to lower vertebrates, the mammalian heart has limited capacity to regenerate after injury in part due to ineffective reactivation of cardiomyocyte proliferation. We show that the microRNA cluster miR302-367 is important for cardiomyocyte proliferation during development and is sufficient to induce cardiomyocyte proliferation in the adult and promote cardiac regeneration. In mice, lo...
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ژورنال
عنوان ژورنال: Stem Cell Research
سال: 2014
ISSN: 1873-5061
DOI: 10.1016/j.scr.2014.09.003